An Important Message Regarding Repellent Claims

Beware of false or exaggerated claims of protection offered by specific repellent products. While the following link to a press release form the New York City’s Attorney General’s Office is aimed at companies attempting to capitalize on the public’s concerns about Zika Virus, it is strong statement that you should only use EPA or CDC recommended repellent ingredients to help prevent mosquito bites.

Repellents, such as DEET, Picaridin and Oil of Lemon Eucalyptus, are an effective tool you can use to protect yourself and your family from mosquito bites and mosquito-borne diseases.

The following information is for domestic use in the United States where EPA-registered products are readily available. Please visit the Center for Disease Control (CDC) Travelers’ Health website for additional information concerning protection from insects when traveling outside the United States.

Choosing a Repellent

The CDC recommends repellents that use products containing active ingredients registered by the U.S. Environmental Protection Agency (EPA) and can be used on the skin and clothing. EPA registration of repellent active ingredients indicates that the materials have been reviewed and approved for efficacy and human safety when applied according to the instructions on the label.

Repellents for Use on Skin & Clothing

CDC evaluation of information contained in peer-reviewed scientific literature and data available from the EPA has identified several EPA registered products that provide repellent activity sufficient to help people avoid the bites of disease carrying mosquitoes.

Products containing the following active ingredients typically provide reasonably long lasting protection.

  • DEET
    Chemical Name: N, N-diethyl-m-toluamide or N, N-diethyl-3-methyl-benzamide
  • Picaridin KBR 3023
    Chemical Name: 2-(2-hydroxyethyl)-1-piperidinecarboxylic acid 1-methylpropyl ester
  • Oil of Lemon Eucalyptus* or PMD
    Chemical Name: para-Menthane-3,8-diol) the synthesized version of oil of lemon eucalyptus IR3535(Chemical Name: 3-[N-Butyl-N-acetyl]-aminopropionic acid, ethyl ester

The EPA characterizes the active ingredients DEET and Picaridin as “conventional repellents” and Oil of Lemon Eucalyptus, PMD and IR535 as “biopesticide repellents”, which are derived from natural materials.

For more information on repellent active ingredients visit the EPA’s website>>

Repellent Efficacy & Duration

Published data indicates that repellent efficacy and duration of protection vary considerably among products and among mosquito species and are markedly affected by ambient temperature, amount of perspiration, and exposure to water, abrasive removal and other factors.

In general, higher concentrations of active ingredient provide longer duration of protection, regardless of the active ingredient, although concentrations above ~50% do not offer a marked increase in protection time. Products with <10% active ingredient may offer only limited protection, often from one to two hours.

Products that offer sustained release or controlled release (micro-
encapsulated) formulations, even with lower active ingredient concentrations, may provide longer protection times.

Regardless of which product you use, if you start to get mosquito bites, reapply the repellent according to the label instructions or remove yourself from the area with biting insects if possible.

Repellents for Use on Clothing

Permethrin is highly effective as an insecticide and as a repellent. Certain products containing permethrin are recommended for use on clothing, shoes, bed nets, and camping gear, and are registered with EPA for this use. Permethrin-treated clothing repels and kills ticks, mosquitoes, and other arthropods and retains this effect after repeated laundering. The permethrin insecticide should be reapplied following the label instructions. Some commercial products are available pretreated with permethrin.

EPA Repellent Recommendations

The EPA recommends the following precautions when using insect repellents:

  • Apply repellents only to exposed skin and/or clothing (as directed on the product label); do not use repellents under clothing
  • Never use repellents over cuts, wounds or irritated skin
  • Do not apply to eyes or mouth, and apply sparingly around ears
  • When using sprays, do not spray directly on face—spray on hands first and then apply to face
  • Do not allow children to handle the product
  • When using on children, apply to your own hands first and then put it on the child
 – you may not want to apply to children’s hands
  • Use just enough repellent to cover exposed skin and/or clothing; heavy application and saturation are generally unnecessary for effectiveness
  • If biting insects do not respond to a thin film of repellent, then apply a bit more
  • After returning indoors, wash treated skin with soap and water or bathe; 
this is particularly important when repellents are used repeatedly in a day or on consecutive days
  • Wash treated clothing before wearing it again – may vary with different repellents—check the product label
  • If you or your child get a rash or other bad reaction from an insect repellent, stop using the repellent, wash the repellent off with mild soap and water, and call a local poison control center for further guidance
  • If you go to a doctor because of the repellent, take the repellent with you to show the doctor
Note that the label for products containing oil of lemon eucalyptus specifies that they should not to be used on children under the age of three years

Other than those listed above, the EPA does not recommend any additional precautions for using registered repellents on children or on pregnant or lactating women. For additional information regarding the use of repellent on children, please see the CDC’s Frequently Asked Questions about Repellent Use.

  • DEET-based repellents applied according to label instructions may be used along with a separate sunscreen; data is not available at this time regarding the use of other active repellent ingredients in combination with a sunscreen

VIsit the EPA’s website for additional information on using EPA-registered repellents.

Please Note: This recommendation refers to EPA-registered repellent products containing the active ingredient oil of lemon eucalyptus (or PMD). “Pure” oil of lemon eucalyptus (e.g. essential oil) has not received similar, validated testing for safety and efficacy, is not registered with EPA as an insect repellent, and is not covered by the CDC recommendation.


  • Barnard DR, Xue RD. Laboratory evaluation of mosquito repellents against Aedes albopictus, Culex nigripalpus, and Ochlerotatus triseriatus (Diptera: Culicidae). J Med Entomol. 2004;41(4):726-30
  • Barnard DR, et al. Repellency of IR3535, KBR3023, para-menthane-3,8-diol, and DEET to Black Salt March mosquitoes Diptera: Culicidae) in the Everglades National Park. J Med Entomol. 2002; 39(6): 895-899
  • Fradin MS, Day JF. Comparative efficacy of insect repellents against mosquito bites. N Engl J Med. 2002; 347(1):13-8
  • Thavara U et al. Laboratory and field evaluations of the insect repellents 3535 (ethyl butyletylaminopropionate) and DEET against mosquito vectors in Thailiand. J of Am Mosq Cont Assoc. 2001, 17(3):190-195